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What kind of drug is doxepin? Summary. Doxepin doxepin (Sinequan and Adapin are discontinued brands in the US; Silenor) is an antidepressant that belongs to the drug class called tricyclic antidepressants. Doxepin is prescribed for depression, anxiety, bipolar disorder, or depression due to alcoholism or brain damage.
Is doxepin time released? The half-life is 15 hours for doxepin and 31 hours for nordoxepin. Doxepin is excreted in urine primarily as glucuronide conjugate. Coadministration with cimetidine, an inhibitor of CYP isoenzymes, could double the doxepin plasma concentration; therefore, patients taking cimetidine should not exceed 3 mg/d of doxepin.
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